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Is Thicker Choroid a Risk Factor for Malignant Glaucoma?

Xiangxi Chen, Xinxing Guo, Xiaoyu Xu

    Ophthalmic Research
    |September 6, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Thicker choroidal thickness (CT) in the fovea is an increased risk factor for malignant glaucoma (MG). Choroidal expansion may significantly contribute to the development of MG in primary angle closure glaucoma (PACG) patients.

    Keywords:
    Choroidal thicknessMalignant glaucomaSpectral-domain optical coherence tomography

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    Area of Science:

    • Ophthalmology
    • Glaucoma Research
    • Anatomy and Physiology

    Background:

    • Primary angle closure glaucoma (PACG) is a significant cause of vision loss.
    • Malignant glaucoma (MG) is a rare but severe complication following glaucoma surgery.
    • Understanding the anatomical factors contributing to MG is crucial for prevention and management.

    Purpose of the Study:

    • To evaluate choroidal thickness (CT) in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG).
    • To identify determinants of CT in PACG eyes.
    • To assess the association between CT and the risk of developing MG.

    Main Methods:

    • Cross-sectional study involving 25 patients with PACG and MG, their fellow eyes, and 37 control PACG eyes.
    • Choroidal thickness (CT) measured at sub-foveal, 1mm, and 3mm from the fovea using spectral-domain optical coherence tomography.
    • Logistic regression analysis to determine associations between CT and MG risk.

    Main Results:

    • Macular CT was significantly thicker in eyes with MG compared to controls (p < 0.001).
    • No significant difference in CT was observed between MG eyes and their fellow eyes.
    • Increased foveal CT was associated with a higher risk of MG (OR 1.141).

    Conclusions:

    • Thicker foveal choroidal thickness is an anatomical risk factor for malignant glaucoma (MG).
    • Choroidal expansion is hypothesized to play a significant role in the development of MG.