Preparation of sulfur nanoparticles and their antibacterial activity and cytotoxic effect
Shiv Shankar1, Rudra Pangeni2, Jin Woo Park2
1Center for Humanities and Sciences, Bionanocomposite Research Center, Department of Food and Nutrition, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Abstract:
Sulfur nanoparticles (SNPs) were prepared using sodium thiosulfate and hydrochloric acid, and the UV-visible spectrum showed the formation of nanoparticulate sulfur. The SNPs were characterized by UV-visible spectrophotometer, transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The antibacterial activity and the cytotoxic effects of the SNPs on the human lung carcinoma (A549), mouse colon carcinoma (CT26), Caco-2, and human fibroblast (CCD-986sk) cells were tested. In addition, the inhibitory effect of the SNPs on the cancer cell migration was evaluated. The SNPs capped with chitosan (SNP2) exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus. SNP2 also effectively inhibited the proliferation and migration of cancer cells with minimal toxic effect on normal cells. SNP2 therefore has potential for medical applications, including those used as antibacterial and chemotherapeutic agents.
Related Concept Videos
The Sulfur Cycle
Sulfur Assimilation
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Co-activators and Co-repressors
tRNA Activation


