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Updated: Feb 5, 2026

Technique for Isolation and Culture of Rat Jaw Bone Marrow Mesenchymal Stem Cells
Published on: May 31, 2024
Early immune response regulated by a bone marrow mesenchymal stem cell model of multiple trauma in rats
Tianlin Wen1, Hao Meng1, Fei Wang1
1Department of Orthopedics, PLA Army General Hospital, Beijing, 100700, China.
Aim:
To explore whether transplantation of bone marrow mesenchymal stem cells (BMSCs) would reduce the immune response and protect vital organs in a rat model of femur shaft fracture combined with craniocerebral injury.
Methods:
The rats were divided into an experimental group (multiple traumas and receiving BMSCs injection, n = 25), a positive control group (only received the combination injuries, n = 25) and a negative group (n = 5).
Results:
Compared with the positive control group, plasma IL-6 and IL-8 were significantly lower at the early stage, and IL-10 was higher at the late period in the experimental group (p < 0.05). TNF-α ex-vivo synthesis descended quickly after trauma.
Conclusion:
BMSCs reduced the inflammatory response and were effective in immunomodulations during severe trauma.
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