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Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
Published on: March 5, 2022
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The RNA Epitranscriptome of DNA Viruses
Brandon Tan1, Shou-Jiang Gao2,3
1Department of Systems Biology, City of Hope, Monrovia, California, USA.
Journal of Virology
|September 7, 2018
Summary
RNA modifications, like N6-methyladenosine (m6A), are crucial in virus gene regulation. Research highlights m6A
Area of Science:
- Virology
- Molecular Biology
- Epigenetics
Background:
- RNA modifications are increasingly recognized for their roles in viral processes.
- N6-methyladenosine (m6A) is the most prevalent mRNA modification in eukaryotes.
- Viruses can harbor endogenous RNA modifications and alter host cell marks.
Purpose of the Study:
- To discuss the significance of m6A in gene regulation within viral systems.
- To review recent advancements concerning m6A in Kaposi's sarcoma-associated herpesvirus (KSHV) and simian virus 40 (SV40).
- To offer perspectives on future research directions for m6A in DNA viruses.
Main Methods:
- Genome-wide scale examination of m6A.
- Review of existing literature on m6A in viral contexts.
- Analysis of KSHV and SV40 research.
Main Results:
- m6A plays a role in the gene regulation of certain viruses.
- Recent studies have provided new insights into m6A's function in KSHV and SV40.
- The field is expanding to explore m6A in other DNA viruses.
Conclusions:
- m6A is a critical RNA modification with implications for viral gene expression.
- Further investigation into m6A in DNA viruses is warranted.
- Understanding m6A mechanisms can lead to novel antiviral strategies.
Keywords:
3′UTR hypermethylation5′UTR hypomethylationKSHVKaposi's sarcoma-associated herpesvirusN6,2′-O-dimethyladenosineN6-methyladenosineSV40YTHDC1YTHDF2epitranscriptomelatency and lytic replicationm6Am6Amsimian virus 40More Related Videos
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