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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Recurrent Mantle Cell Lymphoma Presenting as Gastrointestinal Bleeding
Rafeeq Ahmed1, Kishore Kumar1, Jasbir Makker1
1Division of Gastroenterology, Department of Medicine, BronxCare Hospital Center, Bronx, New York, USA.
Case Reports in Gastroenterology
|September 7, 2018
Summary
Mantle cell lymphoma (MCL) frequently affects the gastrointestinal tract, often presenting as bleeding. Early endoscopic evaluation and biopsy are crucial for diagnosing MCL in patients with GI symptoms, even in recurrent disease.
Area of Science:
- Hematology
- Gastroenterology
- Oncology
Background:
- Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma.
- Gastrointestinal (GI) tract involvement is common in MCL, occurring in over 80% of cases.
- MCL can present with various GI symptoms or be asymptomatic.
Observation:
- Two cases of recurrent MCL presenting with significant GI bleeding are detailed.
- A 58-year-old woman presented with hematochezia due to ascending colon lesions.
- A 68-year-old man presented with melena from a duodenal bulb mass.
Findings:
- Endoscopic biopsies confirmed MCL in both patients.
- GI bleeding, abdominal pain, obstruction, and diarrhea are potential MCL symptoms.
- Biopsies of suspicious and normal mucosa are recommended for diagnosis.
Implications:
- Prompt endoscopic investigation and biopsy are vital for diagnosing GI manifestations of MCL.
- Awareness of GI involvement is critical, especially in recurrent or early-stage disease.
- MCL is initially chemoresponsive but often becomes refractory, highlighting the need for timely diagnosis and management.
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