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Fluorescent contrast agents for tumor surgery.

Qi Xiao1, Tianming Chen2, Shilin Chen3

  • 1School of Life Science, Nanjing Normal University, Nanjing, Jiangsu 210046, P.R. China.

Experimental and Therapeutic Medicine
|September 7, 2018
PubMed
Summary
This summary is machine-generated.

Surgery is crucial for treating solid tumors, but challenges remain in precise tumor removal. Near-infrared fluorescence imaging offers a promising solution for improved surgical accuracy and real-time visualization during cancer surgery.

Keywords:
fluorescence guidance surgeryfluorescent dyesnear infrared

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Area of Science:

  • Oncology
  • Surgical Innovation
  • Medical Imaging

Background:

  • Cancer is a major global cause of mortality, with surgery being the primary curative treatment for solid tumors.
  • Over 50% of cancer patients undergo surgery, significantly increasing cure rates, yet challenges persist in precise lesion identification and complete tumor removal.
  • Current surgical limitations necessitate advanced techniques for improved accuracy and patient outcomes.

Purpose of the Study:

  • To review the application of fluorescence guidance in improving surgical accuracy for solid tumors.
  • To highlight near-infrared fluorescence imaging as a key technology for real-time intraoperative visualization.
  • To introduce different classes of fluorescent dyes utilized in surgical guidance.

Main Methods:

  • Review of preclinical studies on near-infrared fluorescence imaging in surgical oncology.
  • Discussion of passive fluorescent dyes, specifically indocyanine green (FDA-approved).
  • Exploration of fluorescent prodrugs like 5-aminolevulinic acid and biomarker-targeted dyes.

Main Results:

  • Near-infrared fluorescence imaging demonstrates promising results in preclinical studies for early diagnosis and intraoperative imaging.
  • Indocyanine green offers a clinically approved option for passive fluorescence guidance.
  • 5-aminolevulinic acid and targeted dyes represent advanced approaches for enhanced tumor visualization.

Conclusions:

  • Fluorescence guidance, particularly using near-infrared imaging, significantly enhances surgical accuracy in oncology.
  • The development and application of various fluorescent dyes offer versatile tools for intraoperative tumor detection and removal.
  • This technology holds substantial potential to improve cancer treatment outcomes by addressing current surgical challenges.