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Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

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Immunotherapy and Asthma in Children.

Maria A Tosca¹, Amelia Licari², Roberta Olcese¹

¹Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy.

Frontiers in Pediatrics

|September 7, 2018

Summary

Allergen immunotherapy (AIT) is the only disease-modifying treatment for IgE-mediated allergies, improving allergic rhinitis and asthma symptoms. It offers long-lasting effects and may prevent disease progression in children.

Keywords:

allergen immunotherapy allergic rhinitis asthma subcutaneous immunotherapy sublingual immunotherapy

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Published on: May 14, 2012

Area of Science:

Immunology
Allergy and Clinical Immunology
Pediatric Allergy

Background:

Allergen immunotherapy (AIT) is the sole disease-modifying treatment for IgE-mediated allergic diseases.
AIT demonstrates efficacy in improving allergic rhinitis and asthma, including symptom reduction and enhanced quality of life.
Long-lasting effects are observed post-treatment, with recent studies supporting its use in allergic asthma.

Purpose of the Study:

To provide an updated overview of AIT clinical indications.
To focus on pediatric asthma treatment with AIT.
To explore mechanisms of tolerance and predictive biomarkers for AIT response.

Main Methods:

Review of current clinical studies and guidelines on Allergen Immunotherapy.
Analysis of immunological tolerance mechanisms induced by AIT.
Identification of potential biomarkers for predicting treatment response.

Main Results:

Current asthma guidelines recommend sublingual immunotherapy for house dust mite allergy in adults and adolescents.
AIT can reduce the risk of allergic rhinitis progression to asthma in children.
AIT may prevent new allergic sensitizations, indicating a potential preventive role.

Conclusions:

Allergen immunotherapy is a valuable treatment for allergic diseases, with established efficacy and safety.
Its role in pediatric asthma and prevention of allergy progression is increasingly recognized.
Further research into biomarkers could personalize AIT and optimize treatment outcomes.