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Updated: Feb 5, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
[Inflammatory bowel disease and venous thromboembolisms]
N Delhougne1, A Colard2, E Louis1
1Service de Gastroentérologie, CHU Sart Tilman, Liège, Belgique.
Inflammatory Bowel Diseases (IBD) increase the risk of venous thromboembolism, a serious complication often occurring during flares. Prophylactic heparin is effective but underutilized, even for outpatients.
Area of Science:
- Gastroenterology
- Hematology
- Internal Medicine
Background:
- Inflammatory Bowel Diseases (IBD) are linked to significant extra-intestinal complications.
- Venous and arterial thromboembolisms are major causes of morbidity and mortality in IBD patients.
- These thrombotic events frequently coincide with IBD flares and are often triggered by acquired factors.
Purpose of the Study:
- To review the epidemiological and etiological characteristics of thromboembolic events in IBD.
- To discuss the prevention and management strategies for these complications.
- To focus specifically on venous thromboembolisms within the context of IBD.
Main Methods:
- Literature review focusing on epidemiological and etiological data.
- Analysis of current prevention and management guidelines for thromboembolism in IBD.
- Synthesis of information regarding the use of heparin for prophylaxis.
Main Results:
- IBD is a significant risk factor for venous thromboembolism.
- Heparin is an effective preventive measure but is underused.
- Recent guidelines support expanded use of heparin, including for outpatients.
Conclusions:
- Thromboembolism is a critical extra-intestinal manifestation of IBD requiring vigilant management.
- Optimizing the use of prophylactic heparin is crucial for reducing morbidity and mortality.
- Further research and adherence to updated guidelines are needed for effective prevention and treatment.
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