ROLE OF INNATE LYMPHOID CELLS DURING CANCER

It is well known that inflammatory infiltrates in many cases present in the tumor tissue. In addition, to date, convincing evidence for its predictive value for different types of cancer. To the cells of the adaptive immune system, until recently, received more attention but in the last decade has seen a growing number of publications on the participation of innate immunity in cancer processes. This interest is partly due to the fact that in a separate class of innate lymphoid cells were isolated relatively recently. However, when analyzing the literature becomes apparent lack of information about the significance of lymphocytes in vivo innate immunity in the tumor microenvironment formation, angiogenesis, tumor cells motility acquisition and invasive properties, but also for the prediction of the occurrence other forms of progression. This review attempts to structure the available data on the lymphoid cells of the innate immune system, give the brief descriptive characteristics of each subclass, light the question of plasticity of these cells and interaction with the adaptive immune system. Special attention is given to the analysis of the role of the ILC in reparative regeneration as physiological prototype of events that underlie in tumor progression.