[EFFECT OF PROBIOTIC ENTEROCOCCI AND GLATIRAMER ACETATE ON THE SEVERITY OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN...

Area of Science:

• Immunology
• Neuroscience
• Microbiology

Background:

• Intestinal microbiota plays a role in pathologies involving inflammation, autoimmunity, and neurodegeneration.
• Multiple sclerosis (MS) pathogenesis involves these processes and is associated with gut microbiota dysbiosis.
• Probiotics are used to correct gut dysbiosis.

Purpose of the Study:

• To investigate the efficacy of the probiotic strain Enterococcus faecium L-3 in reducing disease severity in experimental allergic encephalomyelitis (EAE), a model for MS.
• To evaluate the combined effect of E. faecium L-3 and glatiramer acetate (GA) on EAE severity.

Main Methods:

• Administration of E. faecium L-3 alone or in combination with GA to rats with EAE.
• Assessment of disease severity in the EAE model.

Main Results:

• E. faecium L-3 administration significantly reduced EAE severity, comparable to GA.
• Combined administration of E. faecium L-3 and GA did not show a synergistic protective effect.
• The study suggests different immune system pathways are modulated by E. faecium L-3 and GA.

Conclusions:

• Enterococcus faecium L-3 demonstrates a significant ability to reduce EAE severity, indicating potential therapeutic value for MS.
• E. faecium L-3 influences the immune system both directly and indirectly via gut dysbiosis correction.
• This probiotic strain is a potential candidate for immunomodulation in autoimmune, inflammatory, and neurodegenerative diseases.