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Familial Waldenström Macroglobulinemia: Families Informing Populations

Mary L McMaster1

  • 1Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, 9609 Medical Center Drive, Room 6E516, MSC 9772, Bethesda, MD 20892-9772, USA; Commissioned Corps of the US Public Health Service, US Department of Health and Human Services, 330 C Street SW, Washington, DC 20416, USA.

Hematology/Oncology Clinics of North America
|September 8, 2018
PubMed

Insights

Familial clustering of Waldenström macroglobulinemia (WM) suggests genetic links. Studies highlight immunoglobulin M monoclonal gammopathy of undetermined significance (IgM MGUS) as a precursor, guiding research into WM susceptibility genes.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Waldenström macroglobulinemia (WM) exhibits familial clustering, observed for decades.
  • Immunoglobulin M monoclonal gammopathy of undetermined significance (IgM MGUS) is a recognized precursor to WM.
  • Family studies have been crucial in understanding WM susceptibility.

Purpose of the Study:

  • To review the role of familial clustering and precursor conditions in Waldenström macroglobulinemia research.
  • To emphasize the importance of IgM MGUS in WM development.
  • To provide a basis for ongoing genetic studies identifying WM predisposition genes.

Main Methods:

  • Review of historical family studies on Waldenström macroglobulinemia.
  • Epidemiological analysis of IgM MGUS and WM.
  • Foundation for genetic investigations into WM susceptibility.

Main Results:

  • Familial aggregation of WM is a consistent observation.
  • IgM MGUS is confirmed as a significant precursor condition for WM.
  • Family and epidemiological data support genetic predisposition research.

Conclusions:

  • Understanding familial links and precursor conditions like IgM MGUS is key to elucidating WM pathogenesis.
  • Further genetic studies are warranted to identify specific WM predisposition genes.
  • Host factors underlying WM development are increasingly understood through these investigations.
Keywords:
Cancer predispositionEnvironmental factorsFamily studiesGenetic susceptibilityWaldenström macroglobulinemia

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