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High-Dose Therapy and Hematopoietic Stem Cell Transplantation in Waldenström Macroglobulinemia

Charalampia Kyriakou1

  • 1Department of Haematology, University College London, Huntley Street, London WC1E 6AG, UK.

Hematology/Oncology Clinics of North America
|September 8, 2018
PubMed

Waldenström macroglobulinemia (WM) is an indolent low-grade non-Hodgkin lymphoma characterized by bone marrow infiltration by lymphoplasmacytic cells and associated clonal IgM paraproteinemia. Recent insights into the biology and genomic characteristics of WM have provided a further platform for more targeted therapies. Despite the high response rates and better depth and duration of responses, the disease remains incurable. This review focuses on use of the high-dose therapy with either autologous or allogeneic hematopoietic stem cell transplantation.

Keywords:
AllogeneicAutologousTransplantationWaldenström macroglobulinemia

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