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Updated: Feb 5, 2026
09:52
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
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A surgical perspective report on melanoma management
Brian D Wernick1,1, Neha Goel2,2, Francis Sw Zih2,2
1St. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA.
Melanoma Management
|September 8, 2018
Summary
Melanoma treatment involves surgical excision and lymph node biopsy. Future management will emphasize immunotherapy and potentially reduce surgical margins and completion lymphadenectomies.
Area of Science:
- Oncology
- Dermatology
- Surgical Oncology
Background:
- Melanoma management involves surgical excision and lymph node biopsy, with completion lymphadenectomy for positive sentinel nodes.
- Locally advanced melanoma requires diverse treatment strategies including surgery, perfusion, infusion, and intralesional therapies.
- Controversy persists regarding the necessity and effectiveness of completion lymphadenectomy in melanoma treatment.
Purpose of the Study:
- To review current and future strategies in melanoma management.
- To discuss the role of surgical interventions and emerging therapies.
- To address the ongoing debate surrounding completion lymphadenectomy.
Main Methods:
- Review of current clinical practices in melanoma management.
- Discussion of various treatment modalities for locally advanced disease.
- Consideration of evidence from ongoing clinical trials, such as MSLT-2.
Main Results:
- Wide excision with adequate margins and lymph node biopsy are standard initial treatments.
- Multiple therapeutic options exist for locally advanced melanoma, including immunotherapy.
- The utility of completion lymphadenectomy remains under investigation.
Conclusions:
- Future melanoma management trends towards increased immunotherapy use.
- There is a potential for narrower surgical margins, especially in sensitive areas.
- The role of completion lymphadenectomy may be limited in future treatment paradigms.
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