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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Biodiversity and Human Values01:24

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Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Requirements for Human Life01:26

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The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
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Proteins are the building block of life. They are also  the most abundant macromolecules with as many diverse roles in the body. They are part of many structural components that provide unique shapes and structures to animal cells, tissues, and organs. In addition, they also act as biological catalysts and carry out several anabolic and catabolic reactions. Notably, some proteins are chemical messengers and regulate many critical processes, such as metabolism, growth, and development. They...
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Maslow's Theory of Basic Human Needs

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Maslow's hierarchy is described with the help of a pyramidal shape. The most fundamental needs, physiological needs, are at the bottom of the pyramid.
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Related Experiment Video

Updated: Feb 5, 2026

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
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Exploring the Uncharacterized Human Proteome Using neXtProt.

Paula Duek, Alain Gateau, Amos Bairoch

    Journal of Proteome Research
    |September 8, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Researchers systematically explored uncharacterized human proteins, proposing functions for 113 and identifying 26 with validated hypotheses. This work aims to accelerate human protein characterization through data integration and collaboration.

    Keywords:
    SPARQLbiocurationcilium biologydata miningfunctional annotationhuman proteinknowledge baseneXtProtsystems biology

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    Area of Science:

    • Human Proteomics
    • Bioinformatics
    • Functional Genomics

    Background:

    • Approximately 10% of the 20,230 predicted human protein-coding genes lack functional annotation.
    • Existing knowledge resources require better integration to accelerate protein characterization.

    Purpose of the Study:

    • To systematically explore and functionally annotate uncharacterized human proteins.
    • To build functional hypotheses for proteins validated at the protein level (uPE1).
    • To encourage collaborative approaches for human proteome characterization.

    Main Methods:

    • Systematic literature exploration for uncharacterized human genes/proteins.
    • Advanced search functionality of neXtProt to analyze proteome landscape.
    • Data mining of public resources to generate functional hypotheses for uPE1 proteins.

    Main Results:

    • Proposed functional annotations for 113 proteins.
    • Consolidated a list of 1,862 uncharacterized human proteins.
    • Generated validated functional hypotheses for 26 uPE1 proteins across diverse biological fields.

    Conclusions:

    • The pace of human protein characterization remains slow despite technological advances.
    • Integrated knowledge resources and collaborative projects are crucial for accelerating discovery.
    • This analysis provides a foundation for collaborative efforts, particularly for the HUPO Human Proteome Project.