Related Experiment Video

Updated: Feb 5, 2026

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

3.5K

His-bundle pacing as a standard approach in patients with permanent atrial fibrillation and bradycardia

Marek Jastrzębski1, Paweł Moskal1, Agnieszka Bednarek1

  • 1First Department of Cardiology, Interventional Electrocardiology and Hypertension, Medical College, Jagiellonian University, Krakow, Poland.

Pacing and Clinical Electrophysiology : PACE
|September 8, 2018
PubMed

Insights

His-bundle (HB) pacing offers physiological ventricular pacing but has challenges. Despite initial lower success rates, HB pacing is a viable alternative for patients with atrial fibrillation and symptomatic bradycardia.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • His-bundle (HB) pacing is the most physiological ventricular pacing method.
  • It is associated with procedural challenges and suboptimal parameters.
  • Limited data exists on HB pacing as a standard approach for symptomatic bradycardia.

Purpose of the Study:

  • To compare acute and chronic outcomes of HB pacing versus right ventricular (RV) myocardial pacing.
  • To evaluate pacing parameters, procedure characteristics, and success rates in patients with permanent atrial fibrillation, narrow QRS, and symptomatic bradycardia.

Main Methods:

  • Retrospective comparison of 125 patients (65 with HB pacing) against historical controls (VVI pacing).
  • Analysis included acute and long-term capture threshold, sensing, battery drain, procedure/fluoroscopy times, complications, and success rates.

Main Results:

  • HB pacing showed higher thresholds, lower sensing, increased current drain, and lower success rates compared to RV pacing.
  • Despite this, long-term HB pacing success was 87.9% with acceptable chronic parameters.
  • HB pacing procedure and fluoroscopy times were longer.

Conclusions:

  • His-bundle pacing can be considered an alternative standard pacing method.
  • It is a viable option for patients with atrial fibrillation and symptomatic bradycardia.
Abstract

Keywords:
His-bundle pacingbradycardiacapture thresholdpermanent atrial fibrillationphysiological pacing

More Related Videos

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K
Robotic Ablation of Atrial Fibrillation11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

20.2K

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.0K
Amyloid Fibrils03:03

Amyloid Fibrils

6.4K
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Standard Enthalpy of Formation02:37

Standard Enthalpy of Formation

Enthalpy changes are typically tabulated for reactions in which both the reactants and products are at the same conditions. A standard state is a commonly accepted set of conditions used as a reference point for the determination of properties under other different conditions. For chemists, the IUPAC standard state refers to materials under a pressure of 1 bar and solutions at 1 M and does not specify a temperature. Many thermochemical tables list values with a standard state of 1 atm. Because...
49.3K
Standard Electrode Potentials03:02

Standard Electrode Potentials

On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.4K
Measurement: Standard Units03:38

Measurement: Standard Units

Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
80.9K