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Updated: Feb 5, 2026

Culture of Neurospheres Derived from the Neurogenic Niches in Adult Prairie Voles
Published on: June 10, 2020
NEUROGENIC NICHE OF THE ADULT MAMMALIAN BRAIN
Abstract:
At the moment, the main location of the regional areas of neural stem cells in the adult brain is considered to be subventricular zone of the lateral ventricles and the dentate gyrus of the hippocampal formation. However, the neural stem cells are not located chaotic in these areas, and they are localized in special niches — structural microenvironment that enables them to maintain identity, affect its proliferation and the fate of her descendants. The components of this microenvironment are intercellular interactions, the relationship with the blood vessels, extracellular matrix and specialized areas of basement membrane. The article describes of the neurogenic niches and the mechanisms controlling cell division and differentiation of progenitor cells.
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