[METABOLIC ACTIVITY OF LUNG AT EXPERIMENTAL BRAIN ISCHEMIA IN CONDITION OF CAPSAICIN BLOCKADE OF VAGUS NERVE]

In rats with ligation of both common carotid arteries in condition of bilateral capsaicin blockade of vagus nerve the metabolic functions of the lungs associated with their participation in the regulation of hemostasis, lipid composition of blood plasma and lung surfactant were investigated. It is shown that cerebral ischemia is accompanied by changes in the fractional composition of phospholipids in both arterial and venous blood, as well as in pulmonary surfactant, and the decrease of the lung hypocoagulation effect. The phagocytic activity of alveolar macrophages (as one of the factors involved in surfactant lipids metabolism) in brain ischemia is reduced. After the blockade of capsaicin-sensitive vagal afferents the changes in surfactant and plasma phospholipids caused by cerebral ischemia, are abolished, hypocoagulation effect of lung restores, but the functional activity of macrophages remains decreased. These findings suggest that capsaicin-sensitive vagal afferents are involved in the development of disregulatory disorders of lung metabolic function in cerebral ischemia.