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Updated: Feb 5, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
Published on: May 14, 2012
[DIRECT EFFECT OF IL-7 ON THE GROWTH AND FUNCTIONAL ACTIVITY OF T-LYMPHOCYTES IN THE ABSENCE OF ANTIGENIC STIMULUS]
Abstract:
It is shown that in the absence of antigenic stimulus interleukin-7 (IL-7) is capable of increasing the content of cells expressing the CD25 molecule among both CD4-positive and CD4-negative effector memory T-cells (CD45RA-CD197-), as well as terminally differentiated T cells (CD45RA+CD197-) without causing a significant impact on the status of the activation of naive T cells (CD45RA+CD197+) and central memory T cells (CD45RA-CD197+). IL-7 was also able to enhance T-cell production of IL-2, interferon-γ (IFN-γ) and IL-10, but not IL-4. These data indicate the involvement of IL-7 into a direct upregulation of growth and functional activity of human T cells in the absence of antigenic stimulus and the relative scarcity of costimulatory effects.
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