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Isolation of Myoepithelial Cells from Adult Murine Lacrimal and Submandibular Glands
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Isolation of Myoepithelial Cells from Adult Murine Lacrimal and Submandibular Glands

Published on: June 11, 2019

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Myoepithelial crowd control of cancer cells

Katharine Goodwin1, Celeste M Nelson2,3

  • 1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.

The Journal of Cell Biology
|September 9, 2018
PubMed

Insights

Smooth muscle-like myoepithelial cells actively remodel mammary gland epithelia. This study reveals a novel mechanism by which these cells suppress mammary gland tumors.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • Smooth muscle-like cells actively remodel epithelial tissues during development.
  • Myoepithelial cells in the mammary gland are smooth muscle-like cells with poorly understood functions.

Purpose of the Study:

  • To investigate the role of mammary gland myoepithelial cells in tissue remodeling.
  • To identify novel mechanisms of tumor suppression involving myoepithelial cells.

Main Methods:

  • The study utilized mouse models and advanced imaging techniques.
  • Analysis of cell-cell interactions and tissue architecture was performed.

Main Results:

  • Myoepithelial cells were shown to actively remodel the mammary gland epithelium.
  • A novel mechanism of tumor suppression mediated by myoepithelial cells was demonstrated.

Conclusions:

  • Mammary gland myoepithelial cells play a critical role in epithelial remodeling.
  • These cells possess a previously unrecognized function in suppressing mammary tumors, offering potential therapeutic insights.

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