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Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
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Regular physical activity and mammographic density: a cohort study.

Shadi Azam1, Katja Kemp Jacobsen2, Arja R Aro3

  • 1Unit for Health Promotion, Department of Public Health, University of Southern Denmark, Niels Bohrs Vej 9, Esbjerg, Denmark. shadi.azam@ki.se.

Cancer Causes & Control : CCC
|September 9, 2018
PubMed
Summary

Regular physical activity, including sports and DIY work, was not found to be a determinant of mammographic density (MD). This study suggests lifestyle factors may not influence breast cancer risk through changes in mammographic density.

Keywords:
Breast densityMammographic densityPhysical activity

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Area of Science:

  • Oncology
  • Epidemiology
  • Radiology

Background:

  • Mammographic density (MD) is a significant risk factor for breast cancer.
  • Physical activity is a modifiable lifestyle factor with potential roles in cancer prevention.
  • Understanding the relationship between physical activity and MD is crucial for breast cancer risk assessment.

Purpose of the Study:

  • To investigate the association between regular physical activity and mammographic density (MD).
  • To determine if participation and duration of physical activities influence breast density.
  • To explore potential effect modification by obesity and menopause status.

Main Methods:

  • Study included 5,703 women from the Danish Diet, Cancer and Health cohort.
  • Mammographic density (MD) was assessed using BI-RADS categories (mixed/dense vs. fatty).
  • Logistic regression models analyzed associations between physical activities (sports, DIY, duration) and MD, adjusting for confounders.

Main Results:

  • A positive association was observed between participation in sports and DIY work and odds of mixed/dense MD, which attenuated after full adjustment.
  • No significant associations were found for time spent on physical activities or total metabolic equivalent of task scores with MD.
  • Obesity and menopause status did not modify the association between physical activities and MD.

Conclusions:

  • Physical activity is not a determinant of mammographic density (MD).
  • The findings suggest that physical activity may not influence breast cancer risk through its effect on mammographic density.