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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Development of New Therapeutic Applications Using Microfluidics
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Serpins: Development for Therapeutic Applications.

Alexandra Lucas1, Jordan R Yaron2, Liqiang Zhang2

  • 1Center for Personalized Diagnostics and Center for Immunotherapy Vaccines and Virotherapy, Biodesign Institute, Arizona State University, 727 E Tyler St, Tempe, AZ, USA. alexluc1@asu.edu.

Methods in Molecular Biology (Clifton, N.J.)
|September 9, 2018
PubMed
Summary
This summary is machine-generated.

Serine protease inhibitors (serpins) regulate vital bodily functions. Dysfunctional serpins cause disease, but therapeutics like virus-derived Serp-1 offer new treatment strategies by modulating immune responses.

Keywords:
Clinical trialDrug developmentPeptidesSerine protease inhibitorsSerpins

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Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Serine protease inhibitors (serpins) are crucial regulators of mammalian homeostasis, impacting processes like blood clotting, immune response, and neurological function.
  • Dysregulation of serpin activity or serine protease function can lead to severe diseases, including serpinopathies and conditions like sepsis, atherosclerosis, and cancer.
  • Therapeutic strategies involve replacing deficient serpins or blocking detrimental serpin actions to restore balance.

Purpose of the Study:

  • To provide an overview of serpin-based drug development.
  • To introduce the development of a virus-derived serpin, Serp-1, as a novel therapeutic agent.
  • To highlight the potential of serpin reactive center loop (RCL) peptides as therapeutics.

Main Methods:

  • Review of existing literature on serpin function and dysfunction.
  • Discussion of therapeutic approaches for serpinopathies and related disorders.
  • Case study on the development of Serp-1 as an immune modulator.

Main Results:

  • Serpins are essential for maintaining physiological balance, and their dysfunction leads to various pathologies.
  • Virus-derived serpins, such as Serp-1, represent a new class of immunomodulatory therapeutics.
  • Serpin RCL peptides are also being developed as potential therapeutic agents.

Conclusions:

  • Serpin-based therapeutics hold significant promise for treating a range of diseases caused by protease-protease inhibitor imbalance.
  • The development of Serp-1 exemplifies a novel approach to serpin-based drug discovery.
  • Further research into serpin-targeted therapies could lead to effective treatments for numerous unmet medical needs.