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Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models
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Corin is highly expressed in atherosclerosis models.

Jingjing Jiang1, Quan Zhou1, Mingcheng Sun1

  • 1Department of Pharmacology, School of Basic Medical Science, Shandong University, Jinan, Shandong, PR China.

Biochemical and Biophysical Research Communications
|September 10, 2018
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Summary

Corin, a heart enzyme, is found in the aorta and increases with atherosclerosis. This suggests corin plays a role in aortic health and disease, offering potential therapeutic targets.

Keywords:
AtherosclerosisCorinEndothelial cellsType II transmembrane serine protease

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Area of Science:

  • Cardiovascular Biology
  • Protease Function
  • Atherosclerosis Research

Background:

  • Corin is a serine protease primarily expressed in the heart, regulating blood pressure via pro-atrial natriuretic peptide (pro-ANP) activation.
  • While known for cardiac function, corin's presence and role in the aorta and atherosclerosis remain unexplored.

Purpose of the Study:

  • To investigate corin expression and its role in the aorta under normal and atherosclerotic conditions.
  • To determine if corin and its substrate pro-ANP are involved in the pathophysiology of atherosclerosis.

Main Methods:

  • In vivo studies using mouse models of atherosclerosis.
  • In vitro studies with cultured vascular endothelial cells.
  • Analysis of corin and pro-ANP expression in aortic tissues and cells.

Main Results:

  • Corin exhibits basal expression in mouse aortic intimal endothelial cells, significantly upregulated in an atherosclerosis model.
  • Pro-ANP, corin's substrate, is also present in mouse aortas and increases during atherosclerosis.
  • Corin expression is induced in cultured vascular endothelial cells by oxidized low-density lipoprotein (ox-LDL) stimulation.

Conclusions:

  • Corin is expressed in the aorta and its levels are altered in atherosclerosis, suggesting a role in aortic physiology and disease.
  • Corin may act in an autocrine manner within the aorta, influencing atherosclerotic processes.
  • Corin represents a potential therapeutic target for atherosclerosis treatment.