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Updated: Feb 5, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Antiquorum sensing and biofilm potential of 5- Hydroxymethylfurfural against Gram positive pathogens
Karuppiah Vijayakumar1, Thiruganasambandam Ramanathan1
1Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India.
Abstract:
The present investigates the antiquorum sensing and biofilm inhibitory potential of 5 - hydroxymethylfurfural against Chromobacterium violaceum, Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus and Staphylococcus epidermidis. 5HMF inhibits the quorum sensing mediated violacein pigment production by 87% at 100 μg/ml concentration. A 100 μg/ml concentration of the compound inhibits S. mutans and S. epidermidis biofilm formation by 86% and 79% whereas for S. pyogenes and S. aureus 125 μg/ml concentration inhibits biofilm formation by 83% and 82%. The Confocal images clearly indicate that 5HMF as a promising antibiofilm agent.
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