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Recurrence-Associated Long Non-coding RNA Signature for Determining the Risk of Recurrence in Patients with Colon

Meng Zhou1, Long Hu2, Zicheng Zhang2

  • 1School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.

Molecular Therapy. Nucleic Acids
|September 10, 2018
PubMed
Summary
This summary is machine-generated.

A novel six-long non-coding RNA signature accurately predicts colon cancer recurrence risk. This molecular marker aids in personalized therapy and improves patient management for better outcomes.

Keywords:
colon cancerlong non-coding RNAsrecurrencesignature

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Colon cancer recurrence poses a significant mortality risk within five years post-treatment.
  • Accurate molecular markers are crucial for developing personalized therapeutic strategies.
  • Current predictive methods require enhancement for improved patient stratification.

Purpose of the Study:

  • To identify and validate a molecular signature for predicting colon cancer recurrence risk.
  • To assess the signature's performance compared to existing clinical and gene-based markers.
  • To explore the functional pathways associated with the identified recurrence signature.

Main Methods:

  • Identification of a six-long non-coding RNA (lncRNA) signature in a discovery cohort of 389 colon cancer patients.
  • Validation of the signature's performance in four independent datasets (906 patients).
  • Multivariate analysis for independent predictive value and in silico functional enrichment analysis.

Main Results:

  • The six-lncRNA signature (LINC0184, AC105243.1, LOC101928168, ILF3-AS1, MIR31HG, AC006329.1) effectively distinguished high-risk from low-risk recurrence.
  • The signature demonstrated robust performance across multiple independent validation cohorts.
  • The lncRNA signature was an independent predictor of recurrence, outperforming clinical factors and known gene signatures.
  • Associated coding genes were enriched in critical cancer pathways like proliferation, angiogenesis, and cell death.

Conclusions:

  • The identified six-lncRNA signature is a robust and independent predictor of colon cancer recurrence.
  • This signature holds significant potential for improving recurrence risk assessment.
  • It can facilitate personalized management strategies for colon cancer patients.