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Haider M Hamzah1, Reyam F Salah2, Mohammed N Maroof3

  • 1Department of Biology, College of Science, University of Sulaimani, Slemani, Kurdistan Region, Iraq.

Journal of Microbiology and Biotechnology
|September 10, 2018
PubMed
Summary

Scientists developed silver nanoparticles (AgNPs) using Fusarium mangiferae. These AgNPs show antibiofilm activity against Staphylococcus aureus and cytotoxic effects on cancer cells, suggesting potential as an antibiotic alternative.

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Eco-friendly fabrication of vanadium nanoparticles <i>via Fusarium solani</i> with dual antifungal and anticancer bioactivities.

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Area of Science:

  • Nanotechnology
  • Microbiology
  • Biochemistry

Background:

  • Developing broad-spectrum medications is a significant scientific challenge.
  • Silver nanoparticles (AgNPs) are explored for their therapeutic potential.
  • Fungal biosynthesis offers a novel route for nanoparticle production.

Purpose of the Study:

  • To synthesize silver nanoparticles (AgNPs) using Fusarium mangiferae.
  • To evaluate the antibiofilm efficacy of AgNPs against Staphylococcus aureus.
  • To assess the cytotoxic effects of AgNPs on mammalian cell lines.

Main Methods:

  • Biosynthesis of AgNPs mediated by Fusarium mangiferae.
  • Characterization of AgNPs using UV-Vis, SEM, TEM, and AFM.
  • Fourier-transform infrared spectroscopy (FTIR) for stability analysis.
Keywords:
Fusarium mangiferaeStaphylococcus aureusantibiofilmmammalian cell linessilver nanoparticles

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  • In vitro assessment of antibiofilm activity and cytotoxicity.

    • Main Results:

    • Well-dispersed AgNPs (25-52 nm) were synthesized, exhibiting UV-Vis absorption around 416-420 nm.
    • FTIR analysis indicated amide compounds responsible for AgNP stability.
    • AgNPs significantly reduced Staphylococcus aureus biofilm formation and induced bacterial cell lysis.
    • Cytotoxicity was observed against HeLa (cervical cancer) and REF (rat embryo fibroblast) cell lines.

    Conclusions:

    • Fusarium mangiferae effectively biosynthesizes stable silver nanoparticles.
    • AgNPs demonstrate potent antibiofilm activity against Staphylococcus aureus.
    • AgNPs exhibit dose-dependent cytotoxicity against mammalian cell lines, warranting further investigation for therapeutic applications.