Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

I Leleu1, B Penaud1, E Blumen-Ohana1

  • 1Centre hospitalier national d'ophtalmologie des 15-20, 28, rue de Charenton, 75012 Paris, France.

Journal Francais D'Ophtalmologie
|September 11, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined Dermis Spacer Graft, Lateral Canthopexy and Subperiosteal Midface Lifting in the Management of Lower Eyelid Retraction Secondary to Chronic Facial Nerve Palsy.

Journal of maxillofacial and oral surgery·2026
Same author

Implementation and evaluation of infection prevention and control training in sub-Saharan Africa.

Infection prevention in practice·2025
Same author

"At home, I never felt included, I always felt on the outside": Deaf peoples' perspectives on how inadequate access to childhood communication influences mental health outcomes.

BMC public health·2025
Same author

[Six-month real-world outcomes of intravitreal clindamycin for ocular toxoplasmosis].

Journal francais d'ophtalmologie·2024
Same author

Changes in rates of endophthalmitis after cataract surgery over the last 23years.

Journal francais d'ophtalmologie·2024
Same author

Orbital solitary fibrous tumor.

Journal francais d'ophtalmologie·2024
Same journal

Silent threat to sight after bariatric surgery: Vision loss from vitamin A deficiency.

Journal francais d'ophtalmologie·2026
Same journal

Persistent subretinal fluid and subretinal precipitates following pneumatic retinopexy.

Journal francais d'ophtalmologie·2026
Same journal

Real-time documentation of acute pre-retinal hemorrhage in central retinal vein occlusion.

Journal francais d'ophtalmologie·2026
Same journal

Incidental detection of benign lobular inner nuclear layer proliferations (BLIPs) in a young adult.

Journal francais d'ophtalmologie·2026
Same journal

Combined autonomic and cranial neuropathy following radiofrequency ablation for trigeminal neuralgia.

Journal francais d'ophtalmologie·2026
Same journal

[Point-of-care biomarkers of ocular surface disease: Current approaches and future perspectives].

Journal francais d'ophtalmologie·2026
See all related articles

Repeated intravitreal anti-VEGF injections (IVI) can cause delayed, severe high intraocular pressure (IOP), sometimes requiring surgery. This serious side effect, though rare, necessitates careful monitoring in patients receiving IVI for conditions like age-related macular degeneration.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Glaucoma Research

Background:

  • Intravitreal anti-VEGF injections (IVI) are standard for exudative age-related macular degeneration (AMD).
  • While steroid-induced ocular hypertension is known, delayed, sustained IOP elevation post-IVI is less recognized.
  • Immediate transient IOP spikes after IVI are common, but chronic effects are often underestimated.

Observation:

  • This study details cases of delayed, severe intraocular pressure (IOP) elevation following repeated intravitreal anti-VEGF injections (IVI).
  • Patients presented with significant IOP spikes despite maximal medical management, necessitating urgent filtering surgery.
  • Optic nerve damage was severe in all reported cases, indicating a critical impact.

Findings:

  • Late-onset, sustained high IOP after repeated IVI, estimated between 2.1% and 13%, increases with injection frequency.
Keywords:
Anti-VEGFElevated intraocular pressureFiltering surgeryGlaucomaIntravitreal injectionNon-penetrating deep sclerectomy

Related Experiment Videos

  • A subset of patients experiences a sudden, severe IOP elevation due to an 'overflow' effect.
  • This phenomenon, though rare, can lead to the need for filtering surgery, even in patients without prior glaucoma or ocular hypertension.

    • Implications:

    • Highlights a potentially underestimated complication of anti-VEGF therapy.
    • Emphasizes the need for vigilant IOP monitoring in patients undergoing repeated IVI.
    • Suggests further research into the pathophysiology and risk factors for sustained IOP elevation post-IVI.