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Related Concept Videos

RNA Structure01:23

RNA Structure

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Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
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RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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Structural Protein Function01:56

Structural Protein Function

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

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Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
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Updated: Feb 5, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Long Non-coding RNA Structure and Function: Is There a Link?

Anna Zampetaki1, Andreas Albrecht2, Kathleen Steinhofel3

  • 1King's British Heart Foundation Centre, King's College London, London, United Kingdom.

Frontiers in Physiology
|September 11, 2018
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are key targets for medicine. This review explores biochemical assays for determining long non-coding RNA (lncRNA) structures and their therapeutic potential.

Keywords:
RNA structurecardiovascular diseasesgene editinglncRNAnon-coding RNA

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulators with diverse biochemical functions.
  • ncRNAs play a role in epigenetic control and are implicated in various diseases.
  • Long non-coding RNAs (lncRNAs) exhibit structural conservation over sequence conservation for function.

Purpose of the Study:

  • To review biochemical assays for determining lncRNA structural configurations.
  • To analyze the implications of linking lncRNA structure and function for therapeutic development.
  • To discuss challenges in designing novel RNA-based therapeutics.

Main Methods:

  • Biochemical assays for structural determination.
  • Analysis of structure-function relationships in lncRNAs.
  • Review of current literature on lncRNA therapeutics.

Main Results:

  • lncRNAs possess complex secondary and tertiary structures.
  • Structural conservation is critical for lncRNA function.
  • Subtle sequence constraints are sufficient for lncRNA function.

Conclusions:

  • Biochemical assays are essential for understanding lncRNA structure.
  • Linking lncRNA structure to function is vital for developing targeted therapies.
  • Further research is needed to overcome challenges in RNA-based therapeutic design.