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Updated: Feb 5, 2026

Probiotic Studies in Neonatal Mice Using Gavage
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Probiotic

Jing Wang1, Haifeng Ji1, Sixin Wang1

  • 1Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.

Frontiers in Microbiology
|September 11, 2018
PubMed
Summary

Probiotic Lactobacillus plantarum ZLP001 strengthens piglet intestinal barriers by enhancing epithelial defenses and beneficial gut bacteria. This probiotic also reduces harmful bacteria, improving gut health post-weaning.

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Area of Science:

  • Animal Science
  • Microbiology
  • Gastroenterology

Background:

  • Weaning compromises intestinal barrier function and increases infection risk in piglets.
  • Probiotics can improve gut health by reinforcing the intestinal epithelium and modulating gut microbiota.
  • Mechanisms of probiotic action on intestinal epithelium and microbiota require further elucidation.

Purpose of the Study:

  • To investigate the protective effects of Lactobacillus plantarum ZLP001 on the piglet intestinal epithelium and microbiota.
  • To determine how modulated microbiota by L. plantarum ZLP001 influences epithelial function.

Main Methods:

  • Assessed paracellular permeability using fluorescein isothiocyanate-dextran (FD-4).
  • Measured tight junction (TJ) proteins, proinflammatory cytokines, and host defense peptides via RT-qPCR, ELISA, and western blot.
Keywords:
Lactobacillus plantarumhost defenseimmune responsemicrobiotapermeabilitytight junction

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  • Analyzed short-chain fatty acid (SCFA) concentrations and fecal microbiota composition using ion chromatography and high-throughput sequencing.

    • Main Results:

    • L. plantarum ZLP001 counteracted enterotoxigenic Escherichia coli (ETEC)-induced gut permeability and TJ protein reduction.
    • The probiotic downregulated proinflammatory cytokines (IL-6, IL-8, TNFα) and increased host defense peptides (pBD2, PG1-5).
    • L. plantarum ZLP001 increased beneficial butyrate-producing bacteria (Anaerotruncus, Faecalibacterium) and Lactobacillus, while decreasing Clostridium sensu stricto 1.

    Conclusions:

    • L. plantarum ZLP001 enhances intestinal barrier function in piglets.
    • The probiotic strengthens epithelial defense mechanisms and modulates gut microbiota composition.
    • These actions contribute to improved gut health and reduced infection risk in weaned piglets.