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Obstructive sleep apnea and severity of coronary artery disease

Ali Vasheghani-Farahani1, Fatemeh Kazemnejad2, Khosro Sadeghniiat-Haghighi3

  • 1Cardiac Primary Prevention Research Center (CPPRC), Tehran Heart Center, Tehran University of Medical Sciences Tehran, Iran.

Caspian Journal of Internal Medicine
|September 11, 2018
PubMed

Insights

Obstructive sleep apnea (OSA) is independently associated with coronary artery disease (CAD). Increased severity of OSA, measured by the Multivariable apnea prediction (MAP) index, correlated with higher Gensini scores, indicating more severe atherosclerosis.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Vascular Biology

Background:

  • Obstructive sleep apnea (OSA) is linked to cardiovascular diseases like stroke, myocardial infarction, coronary artery disease (CAD), and hypertension.
  • Atherosclerosis is a key contributor to cardiovascular morbidity and mortality.

Purpose of the Study:

  • To investigate the correlation between obstructive sleep apnea (OSA) and the severity of atherosclerosis.
  • To assess the association between OSA and coronary artery disease (CAD) severity using angiography.

Main Methods:

  • 337 patients undergoing coronary angiography were assessed.
  • Obstructive sleep apnea (OSA) was evaluated using the Multivariable apnea prediction (MAP) risk index.
  • Coronary angiograms were scored using the Gensini score to quantify atherosclerosis severity.

Main Results:

  • The prevalence of three-vessel disease was significantly higher in the OSA group (68.0%) compared to the non-OSA group (32.0%).
  • The Multivariable apnea prediction (MAP) index was identified as the most significant independent determinant of the Gensini score.
  • Gensini scores demonstrated a positive correlation with increasing MAP values.

Conclusions:

  • Obstructive sleep apnea (OSA) shows an independent association with coronary artery disease (CAD).
  • OSA should be considered a significant risk factor for CAD, even after accounting for traditional confounders.
  • These findings highlight the importance of evaluating OSA in patients with or at risk for CAD.
Abstract

Keywords:
AtherosclerosisCoronary angiographyCoronary artery diseaseGensini scoreObstructive sleep apnea

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