Prostate specific antigen and relative prostate weight data on effect of

Area of Science:

• Urology
• Pharmacology
• Phytochemistry

Background:

• Benign prostatic hyperplasia (BPH) is a prevalent condition in aging men, causing lower urinary tract symptoms due to prostate enlargement.
• Current treatments for BPH have limitations and side effects, driving research into alternative therapies.

Purpose of the Study:

• To investigate the efficacy of Tetracarpidium conophorum extract in a testosterone-induced rat model of BPH.
• To evaluate the impact of the extract on prostate weight and prostate-specific antigen (PSA) levels.

Main Methods:

• BPH was induced in rats using testosterone propionate injections over three weeks.
• Rats were treated daily with varying doses of Tetracarpidium conophorum extract (100, 200, 400 mg/kg) or finasteride (5 mg/kg).
• Prostate weight, relative prostate weight, and PSA levels were measured at the study's end. Phytochemical screening was also performed.

Main Results:

• Tetracarpidium conophorum extract significantly reduced prostate weight and relative prostate weight in a dose-dependent manner.
• PSA levels were notably decreased in rats treated with 200 and 400 mg/kg of the extract compared to the BPH control group.
• Phytochemical analysis confirmed the presence of beneficial compounds like flavonoids, tannins, phenols, and steroids in the extract.

Conclusions:

• Tetracarpidium conophorum extract demonstrates significant anti-BPH activity in a preclinical model.
• The extract's ability to reduce prostate size and PSA levels suggests its therapeutic potential for managing BPH.