Radiotherapy for parotid IgG4-related disease

Area of Science:

• Immunology
• Oncology
• Radiology

Background:

• Immunoglobulin G4-related disease (IgG4-RD) is a rare fibroinflammatory condition.
• Parotid gland involvement in IgG4-RD can mimic other conditions like Kimura's disease.
• Accurate diagnosis and treatment of IgG4-RD are crucial for patient outcomes.

Observation:

• A 37-year-old male presented with parotid gland enlargement, initially diagnosed as Kimura's disease.
• The patient received radiotherapy for the misdiagnosed condition.
• Sustained partial response was observed following radiotherapy.

Findings:

• The case demonstrates the successful use of radiotherapy for parotid IgG4-related disease.
• This represents the first reported instance of radiotherapy for extra-orbital IgG4-RD.
• The inadvertent use of radiation yielded a positive therapeutic effect.

Implications:

• Radiotherapy may be a viable treatment option for parotid IgG4-RD.
• This case underscores the importance of considering IgG4-RD in differential diagnoses of parotid masses.
• Further research is warranted to explore the role of radiotherapy in IgG4-RD management.