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[THE ROLE OF FIBROBLAST GROWTH FACTOR 21 (FGF21) IN THE REGULATION AND CORRECTION OF CARBOHYDRATE AND LIPID

E N Marakova, N M Bazhan

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |September 11, 2018
    PubMed

    Insights

    Fibroblast growth factor 21 (FGF21) is a key metabolic hormone that improves insulin sensitivity and carbohydrate/lipid metabolism. FGF21 shows promise as a therapeutic for obesity and Type II diabetes.

    Area of Science:

    • Endocrinology
    • Metabolic research
    • Pharmacology

    Background:

    • Obesity and Type II diabetes require novel therapeutic targets for metabolic regulation.
    • Fibroblast growth factor 21 (FGF21) is an endocrine hormone regulating energy homeostasis.
    • FGF21 plays a role in adaptation to starvation and low temperatures.

    Purpose of the Study:

    • To review the physiological and pharmacological mechanisms of FGF21's anti-diabetic actions.
    • To highlight recent advances in understanding FGF21's role in metabolic health.

    Main Methods:

    • Literature review of studies on FGF21.
    • Analysis of FGF21's effects on insulin sensitivity, carbohydrate, and lipid metabolism.
    • Examination of FGF21's impact on energy expenditure and body weight in preclinical models.

    Main Results:

    • FGF21 administration in rodents improves insulin sensitivity and reduces blood glucose and insulin levels.
    • FGF21 reduces body weight and fat mass by increasing energy expenditure.
    • FGF21 is identified as a crucial factor in maintaining energy homeostasis.

    Conclusions:

    • FGF21 is a promising therapeutic candidate for treating obesity and Type II diabetes.
    • Understanding FGF21's mechanisms is vital for developing new pharmacological strategies.
    • FGF21 normalizes key metabolic parameters relevant to diabetes and obesity.

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