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Updated: Feb 5, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression
Li-Ning Jiang1, Ya-Bin Liu, Bing-Hui Li
1Department of Surgery II, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China Department of Urology Surgery I, Cangzhou Central Hospital, Cangzhou 061000, China.
Abstract:
Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-α (TNF-α), in lycopene-treated cells were also reduced by lycopene treatment. With the increasing dose of lycopene, the survival of mice bearing prostate cancer xenografts was significantly improved ( P < 0.01), and the tumor burden was significantly reduced ( P < 0.01). Our results indicate that lycopene is a promising chemotherapy drug, which inhibits prostate cancer progression by suppressing the inflammatory response.
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