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Updated: Feb 5, 2026

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
Published on: November 21, 2023
[INVOLVEMENT OF р38 МАРК OF SENSORY NEURONS IN OUABAIN-ACTIVATED SIGNALING CASCADE]
Abstract:
Recent investigations of the new transducting function of Na+,K+-АTPase is of great interest. Na+,K+-АTPase might be a target (receptor) for cardiotonic steroids. This membrane protein switches on intracellular signaling mechanisms due to its ligand-receptor interactions with the steroids that, in turn, result in activation of intracellular cascade processes. р38 belongs to mito-gen-activated protein kinase family (MAPK). The kinase transduces signals of wide range intra-cellular signaling cascades that control proliferation, differentiation, and survival. Using embryonic organotypic tissue culture method the present work shows that р38 МАРК is involved in the signal transducting process in series with Na+,K+-АTPase.
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