Related Experiment Video

Updated: Feb 5, 2026

Preparation of CD4+ T Cells for Analysis of GD3 and GD2 Ganglioside Membrane Expression by Microscopy
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Preparation of CD4+ T Cells for Analysis of GD3 and GD2 Ganglioside Membrane Expression by Microscopy

Published on: November 8, 2016

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Disialoganglioside GD2 Expression in Pediatric Rhabdomyosarcoma: A Case Series and Review of the Literature

Amanda J Saraf1, Paul S Dickman2, Pooja Hingorani2

  • 1Nationwide Children's Hospital, Columbus, OH.

Journal of Pediatric Hematology/Oncology
|September 11, 2018
PubMed

Insights

Rhabdomyosarcoma (RMS), a common pediatric cancer, needs new treatments. This study found disialoganglioside (GD2) in 25% of RMS samples, suggesting it could be a therapeutic target for some patients.

Area of Science:

  • Pediatric Oncology
  • Cancer Immunology
  • Molecular Pathology

Background:

  • Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children.
  • Current treatments for metastatic or relapsed RMS offer poor prognoses, highlighting the need for novel therapeutic strategies.
  • Disialoganglioside (GD2) is a cell surface antigen recognized for its potential as a therapeutic target in various cancers.

Observation:

  • This research investigated the expression of disialoganglioside (GD2) in a cohort of 16 Rhabdomyosarcoma patient samples.
  • GD2 expression was assessed using a scoring system to quantify its presence on tumor cells.

Findings:

  • Disialoganglioside (GD2) positivity was detected in 25% of the evaluated Rhabdomyosarcoma samples.
  • These findings indicate that a specific subset of pediatric RMS tumors express GD2.

Implications:

  • The presence of GD2 in a fraction of RMS tumors suggests its potential utility as a targeted therapeutic agent.
  • Further research into GD2-targeted therapies could offer new treatment avenues for patients with Rhabdomyosarcoma, particularly those with advanced or recurrent disease.

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