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Updated: Feb 5, 2026

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
Published on: February 17, 2023
Network meta-analysis of topical haemostatic agents in thyroid surgery
G Polychronidis1,2, F J Hüttner1,2, P Contin1,2
1Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Local haemostatic agents do not reduce clinically relevant bleeding after thyroidectomy. While active haemostatic agents reduced blood loss and operating time, they did not lower the rate of cervical haematoma requiring reoperation.
Area of Science:
- Surgical Innovation
- Evidence-Based Medicine
- Clinical Trials
Background:
- Postoperative bleeding is a concern after thyroidectomy.
- Local haemostatic agents are used to control bleeding.
- Their efficacy in reducing reoperation rates requires evaluation.
Purpose of the Study:
- To assess the effectiveness of local haemostatic agents in preventing postoperative bleeding after thyroidectomy.
- To compare active haemostatic agents (AHA) and passive haemostatic agents (PHA) against control and each other.
Main Methods:
- Systematic literature search for randomized controlled trials (RCTs).
- Network meta-analysis using a Bayesian random-effects model.
- Primary outcome: rate of cervical haematoma requiring reoperation.
Main Results:
- Thirteen RCTs were included.
- Haemostatic agents did not reduce the rate of cervical haematoma requiring reoperation.
- Active haemostatic agents (AHA) significantly reduced total postoperative blood loss and operating time compared to control and passive haemostatic agents (PHA).
Conclusions:
- General use of local haemostatic agents is not proven to reduce clinically relevant bleeding after thyroidectomy.
- Specific agents may offer benefits in blood loss and operative time but not in reducing reoperation rates.
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