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Updated: Feb 5, 2026
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Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
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Screening for morbidly adherent placenta in early pregnancy
J Panaiotova1, M Tokunaka1, K Krajewska1
1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Summary
A two-stage ultrasound strategy accurately predicts morbidly adherent placenta (MAP). High-risk pregnancies identified early can be confirmed with specialized ultrasound at 12-16 weeks gestation.
Area of Science:
- Obstetrics and Gynecology
- Fetal Medicine
- Diagnostic Imaging
Background:
- Morbidly adherent placenta (MAP) is a significant obstetric complication.
- Early prediction of MAP is crucial for improved maternal outcomes.
- Current diagnostic methods may lack accuracy in early gestation.
Purpose of the Study:
- To evaluate a two-stage ultrasound strategy for early prediction of MAP.
- To determine the diagnostic accuracy of this strategy.
- To identify pregnancies at high risk for MAP.
Main Methods:
- Prospective study involving 22,604 singleton pregnancies.
- Stage 1: Ultrasound at 11-13 weeks gestation to identify high-risk cases (low-lying placenta and history of uterine surgery).
- Stage 2: Specialist MAP clinic assessment at 12-16 weeks using specific ultrasound markers (e.g., placental vascularization, myometrial thinning).
Main Results:
- 6% of pregnancies (1298/22,604) were identified as high-risk at 11-13 weeks.
- MAP was suspected in 14 high-risk cases at 12-16 weeks.
- 13 of these suspected cases were confirmed as MAP at delivery.
Conclusions:
- A two-stage ultrasound approach enables accurate prediction of MAP.
- Specialized ultrasound examination between 12-16 weeks gestation is effective for MAP diagnosis.
- This strategy aids in early identification and management of MAP.
Keywords:
first trimestermorbidly adherent placentaplacenta accretaprenatal diagnosisultrasound screeningMore Related Videos
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