[ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY].

Area of Science:

• Pulmonary Medicine
• Pharmacology

Background:

• Chronic obstructive pulmonary disease (COPD) involves chronic inflammation and structural damage to the lungs.
• Nitrogen dioxide exposure is a model for inducing COPD-like changes in animal studies.
• The bronchial epithelium plays a critical role in lung health and disease pathogenesis.

Purpose of the Study:

• To investigate the therapeutic effects of the tetrapeptide bronchogen on COPD.
• To evaluate bronchogen's impact on bronchial epithelium structure and function.
• To assess changes in lung inflammation and immune markers following bronchogen treatment.

Main Methods:

• A rat model of COPD was established using 60-day intermittent nitrogen dioxide exposure.
• Bronchoalveolar lavage fluid (BALF) was analyzed for cell composition and cytokine-enzyme profiles.
• Levels of secretory immunoglobulin A (sIgA) and surfactant protein B (SP-B) in BALF were quantified.

Main Results:

• Bronchogen treatment reduced neutrophilic inflammation in the bronchoalveolar space.
• Normalization of cellular composition and pro-inflammatory mediators was observed.
• Restoration of bronchial epithelium structure and function, indicated by increased sIgA and SP-B levels.

Conclusions:

• The tetrapeptide bronchogen demonstrates significant therapeutic potential for COPD.
• Bronchogen effectively mitigates lung inflammation and promotes epithelial repair in a COPD model.
• Restoration of local immunity and alveolar function are key outcomes of bronchogen therapy.