Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Technetium-sulfur colloid.

J Steigman, N A Solomon, L L Hwang

    International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sympathoinhibitory action of nociceptin in the rat spinal cord.

    Clinical and experimental pharmacology & physiology·2002
    Same author

    Mechanisms of orexin-induced depolarizations in rat dorsal motor nucleus of vagus neurones in vitro.

    The Journal of physiology·2001
    Same author

    Orexins: a role in medullary sympathetic outflow.

    Regulatory peptides·2000
    Same author

    Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats.

    American journal of physiology. Regulatory, integrative and comparative physiology·2000
    Same author

    Serotonin modulates synaptic transmission in immature rat ventrolateral medulla neurons in vitro.

    Neuroscience·1999
    Same author

    Cost-effectiveness of alternative test strategies for the diagnosis of coronary artery disease.

    Annals of internal medicine·1999
    Same journal

    A universal water target loading system with direct in-target liquid level sensing.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1992
    Same journal

    Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1992
    Same journal

    Preparation of [131I]lipiodol as a hepatoma therapeutic agent.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1992
    Same journal

    Targeting of [111In]biocytin to cultured ovarian adenocarcinoma cells using covalent monoclonal antibody-streptavidin conjugates.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1992
    Same journal

    Development of 3-iodophenylisothiocyanate for radioiodination of monoclonal antibodies.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1992
    Same journal

    A simple synthesis of [11C]methyl triflate.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1992
    See all related articles

    Technetium-sulfur colloid formation involves initial technetium sulfide nuclei, followed by sulfur deposition. Adjusting pH can yield smaller, sulfur-free particles for effective lymphograms.

    Area of Science:

    • Radiochemistry
    • Colloid Science
    • Nuclear Medicine Imaging

    Background:

    • Technetium-sulfur colloids are used in medical imaging.
    • Understanding their formation is crucial for optimizing radiopharmaceutical properties.

    Purpose of the Study:

    • Investigate the chemical composition and particle characteristics of technetium-sulfur colloid.
    • Determine the formation mechanism and explore methods for particle size modification.

    Main Methods:

    • Reaction of sodium thiosulfate with acid to produce technetium-sulfur colloid.
    • Filtration of colloidal dispersions through graded membranes.
    • Analysis of elemental sulfur, bisulfite, and residual thiosulfate.
    • Determination of sulfur and 99mTc percentages in filtrates.

    Related Experiment Videos

    Main Results:

    • Agreement between sulfur and 99mTc percentages for particles >= 0.4 micron.
    • Small particles (< 0.1 micron) showed minimal sulfur but significant technetium.
    • Alkaline pH treatment and reheating dissolved sulfur, yielding smaller, sulfur-free Tc-S particles.
    • Potassium trithionate produced smaller Tc-S particles with less sulfur.

    Conclusions:

    • Technetium sulfide nuclei form first, followed by sulfur deposition.
    • Particle size and composition can be controlled by adjusting preparation conditions (e.g., pH).
    • Modified technetium-sulfur colloid is efficient for lymphography, comparable to technetium-antimony sulfide colloid.