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Developing a Rat Model for Bipolar Disorder
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Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder.
Rikinkumar S Patel1, Sanya Virani2, Hina Saeed3
1Department of Psychiatry, Griffin Memorial Hospital, 900 E Main St, Norman, OK 73071, USA. dr.rknpatel@gmail.com.
Brain Sciences
|September 12, 2018
Summary
Women with bipolar disorder experience a greater burden of medical and psychiatric comorbidities than men. Integrated care teams can improve health outcomes for these patients.
Area of Science:
- Psychiatry
- Internal Medicine
- Epidemiology
Background:
- Bipolar disorder is frequently associated with various comorbidities.
- Previous research has explored these associations, but gender-specific differences require further investigation.
Purpose of the Study:
- To analyze gender-based differences in the prevalence and association of medical and psychiatric comorbidities among patients diagnosed with bipolar disorder.
Main Methods:
- Retrospective analysis of the Nationwide Inpatient Sample (2010-2014).
- Utilized International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes to identify patients with primary bipolar disorder diagnosis and their comorbidities.
- Employed chi-square tests and logistic regression (odds ratio) to quantify gender-based differences.
Main Results:
- Top medical comorbidities in bipolar patients included hypertension (20.5%), asthma (12.5%), and hypothyroidism (8.1%).
- Females exhibited significantly higher odds for migraine (OR=3.074) and hypothyroidism (OR=3.001).
- Females had increased odds for inflammatory disorders (asthma, Crohn's disease, multiple sclerosis), PTSD, personality disorders, and anxiety disorders compared to males.
Conclusions:
- Women with bipolar disorder face a substantially higher burden of medical comorbidities compared to men.
- An integrated medical team approach is recommended to manage bipolar disorder comorbidities in women, potentially improving their quality of life.
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