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Detection of Functional Overreaching in Endurance Athletes Using Proteomics
David C Nieman1, Arnoud J Groen2, Artyom Pugachev3
1North Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA. niemandc@appstate.edu.
Proteomes
|September 12, 2018
Summary
Researchers identified 13 blood proteins linked to functional overreaching (FOR) in athletes. This discovery could lead to new biomarkers for monitoring training states and preventing overtraining syndrome (OTS).
Area of Science:
- Sports Science
- Biochemistry
- Proteomics
Background:
- Reliable biomarkers for athletic training states like functional overreaching (FOR), non-functional overreaching (NFOR), and overtraining syndrome (OTS) are currently lacking.
- Understanding these states is crucial for optimizing athletic performance and preventing injury.
Purpose of the Study:
- To identify blood protein biomarkers associated with functional overreaching (FOR) using a systems-wide proteomics approach.
- To establish a foundation for developing diagnostic tools for monitoring athletic training status.
Main Methods:
- A proteomics approach using nanoLC-MS in data-independent acquisition (DIA) mode on dried blood spot samples (DBS).
- Participants underwent a controlled functional overreaching protocol or a rest period, serving as their own controls.
- Statistical analysis using generalized estimating equation (GEE) to identify proteins linked to FOR.
Main Results:
- 593 proteins were identified and quantified from DBS samples.
- A panel of 13 proteins was significantly linked to the functional overreaching state.
- The identified proteins were predominantly associated with the acute phase response and innate immune system activation.
Conclusions:
- This study successfully identified a panel of 13 blood proteins associated with functional overreaching (FOR).
- These proteins show potential as biomarkers for monitoring athletic training states.
- Further research is warranted to explore these biomarkers for NFOR and OTS detection.
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