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Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica
Published on: August 23, 2018
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The Effect of Permethrin Resistance on
Liming Zhao1, Barry W Alto2, Dongyoung Shin3
1Florida Medical Entomology Laboratory, University of Florida, 200 9th Street South East, Vero Beach, FL 32962, USA. lmzhao@ufl.edu.
Viruses
|September 12, 2018
Summary
Insecticide resistance in Aedes aegypti mosquitoes, the primary arbovirus vector, was studied using RNA-sequencing. Zika virus infection altered gene expression in resistant mosquitoes, highlighting potential P450 targets for control.
Area of Science:
- * Molecular biology and entomology, focusing on vector-borne diseases and insecticide resistance.
Background:
- * Aedes aegypti mosquitoes are significant vectors for emerging arboviruses like Zika.
- * Insecticide resistance in mosquito populations complicates disease control efforts.
Purpose of the Study:
- * To compare transcriptomes of permethrin-resistant and susceptible Aedes aegypti strains after Zika virus infection.
- * To identify molecular mechanisms underlying insecticide resistance and Zika virus interactions.
Main Methods:
- * RNA-sequencing to analyze gene expression differences between resistant and susceptible mosquito strains.
- * Quantitative real-time PCR to validate gene expression changes in response to Zika virus.
Main Results:
- * 2459 transcripts showed significant expression differences between resistant and susceptible Aedes aegypti.
- * Highly overexpressed P450 enzymes (AAEL014617, AAEL006798) were identified as potential contributors to permethrin resistance.
- * Zika virus infection altered gene expression of detoxification and immune enzymes in resistant mosquitoes.
Conclusions:
- * Zika virus infection impacts gene expression in insecticide-resistant Aedes aegypti.
- * Understanding these molecular interactions can inform novel mosquito and arbovirus control strategies.
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