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Ravichandra Vemuri1, Tanvi Shinde2,3, Rohit Gundamaraju4

  • 1School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7250, Australia. ravichandra.vemuri@utas.edu.au.

Nutrients
|September 12, 2018
PubMed
Summary

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This summary is machine-generated.

Probiotic Lactobacillus acidophilus DDS-1 improved gut microbiota and metabolism in aging mice. This suggests potential for probiotics to counteract age-related metabolic changes.

Area of Science:

  • Microbiology
  • Metabolomics
  • Gerontology

Background:

  • Gut microbiota composition changes with age, impacting host metabolism.
  • Lactobacillus acidophilus DDS-1 is a probiotic strain with demonstrated efficacy.
  • Aging is associated with shifts in gut microbial populations and metabolic alterations.

Purpose of the Study:

  • To investigate the effects of Lactobacillus acidophilus DDS-1 on gut microbiota and host metabolism in young and aging mice.
  • To determine if DDS-1 can modulate age-related gut microbial shifts and metabolic phenotypes.

Main Methods:

  • 16S rRNA gene sequencing for gut microbiota analysis.
  • Untargeted gas chromatography-mass spectrometry (GC-MS) for metabolomics.
  • Principal coordinate analysis (PCoA) for microbiota comparison.
Keywords:
aginggut microbiotametabolismprobiotics

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  • Analysis of metabolic pathways in young and aging mice with and without DDS-1 treatment.

    • Main Results:

    • Gut microbial shifts and metabolic alterations were observed in control aging mice.
    • L. acidophilus DDS-1 treatment resulted in distinct microbiota profiles.
    • DDS-1 increased beneficial bacteria (Akkermansia muciniphila, Lactobacillus spp.) and decreased opportunistic bacteria (Proteobacteria spp.).
    • Metabolic pathway analysis revealed modulation in amino acid, protein, carbohydrate, and butanoate metabolism.

    Conclusions:

    • Lactobacillus acidophilus DDS-1 effectively modulates gut microbiota composition.
    • DDS-1 treatment improves the metabolic phenotype in aging mice.
    • Probiotic intervention with DDS-1 shows promise for mitigating age-related metabolic decline.