Related Experiment Video

Updated: Feb 5, 2026

Author Spotlight: Visualizing Single-Stranded DNA During DNA Repair for Therapeutic Insights
08:30

Author Spotlight: Visualizing Single-Stranded DNA During DNA Repair for Therapeutic Insights

Published on: December 22, 2023

3.4K

Hyperoside and let-7a-5p synergistically inhibits lung cancer cell proliferation via inducing G1/S phase arrest

Jia-Peng Li1, Xing-Hua Liao1, Yuan Xiang1

  • 1Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Hubei 430081, PR China.

Gene
|September 12, 2018
PubMed

Insights

Hyperoside and microRNA-let-7a-5p synergistically inhibit lung cancer cell proliferation by inducing apoptosis and cell cycle arrest. This combination therapy offers a promising new avenue for treating lung cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Lung cancer is a highly aggressive malignancy with poor survival rates.
  • Hyperoside, a flavonol glycoside, exhibits anti-cancer properties.
  • MicroRNA-let-7 (let-7) acts as a tumor suppressor in various human cancers.

Purpose of the Study:

  • To investigate the combined effects of hyperoside and let-7a-5p on A549 lung cancer cell proliferation, cell cycle, and apoptosis.
  • To elucidate the underlying molecular mechanisms of hyperoside and let-7a-5p in lung cancer suppression.

Main Methods:

  • In vitro study using A549 lung cancer cell line.
  • Assessment of cell proliferation, apoptosis, and cell cycle distribution.
  • Analysis of microRNA-let-7a-5p expression and its target gene CCND1.

Main Results:

  • Hyperoside inhibited A549 cell proliferation by inducing apoptosis and G1/S phase arrest.
  • Let-7a-5p suppressed A549 cell proliferation by inhibiting G1/S phase progression.
  • Hyperoside and let-7a-5p demonstrated a synergistic effect in suppressing lung cancer cell proliferation.
  • MicroRNA-let-7a-5p was found to directly regulate CCND1 expression in A549 cells.

Conclusions:

  • Hyperoside and microRNA-let-7a-5p exhibit a synergistic anti-cancer effect against lung cancer cells.
  • The combination of hyperoside and let-7a-5p may offer a novel therapeutic strategy for lung cancer treatment.
Keywords:
CCND1HyperosideLet-7a-5pLung cancerProliferation

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.4K
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.2K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Phase Diagrams02:39

Phase Diagrams

A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.3K