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Relationship between perioperative thyroid function and acute kidney injury after thyroidectomy.
Eun-Young Joo1, Yeon Ju Kim1, Yonji Go1
1Department of Anaesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Scientific Reports
|September 12, 2018
Summary
Postoperative hypothyroidism may increase the risk of acute kidney injury (AKI) after thyroidectomy. Preoperative thyroid function did not impact AKI risk, but male sex and beta-blocker use were significant factors.
Area of Science:
- Nephrology
- Endocrinology
- Surgical Research
Background:
- Thyroid dysfunction can impact kidney function through direct and systemic effects.
- Limited data exists on the relationship between thyroid status and postoperative acute kidney injury (AKI) following thyroidectomy.
Purpose of the Study:
- To investigate the association between preoperative and postoperative thyroid function and the incidence of AKI after thyroidectomy.
- To identify risk factors for AKI in patients undergoing thyroidectomy.
Main Methods:
- Retrospective review of 486 patients who underwent thyroidectomy between 2010 and 2014.
- Thyroid function assessed via free thyroxine or thyroid-stimulating hormone levels.
- AKI diagnosis based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria.
Main Results:
- The overall incidence of postoperative AKI was 4.9% (24 patients).
- No significant association was found between preoperative thyroid function and AKI.
- Patients with postoperative hypothyroidism had a higher AKI incidence (19.4%) compared to euthyroid (6.7%) or hyperthyroid (0%) patients (P=0.044).
- Independent risk factors for AKI included male sex, preoperative beta-blocker use, low preoperative serum albumin, and colloid administration.
Conclusions:
- Postoperative hypothyroidism is a potential risk factor for AKI following thyroidectomy.
- Male sex, preoperative beta-blocker use, low serum albumin, and colloid administration are associated with increased AKI risk post-thyroidectomy.
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