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Can Interpreting Nonsignificant Findings Inform the Lessons Learned From an Intervention?
Nicole Dawson1,2, Heather Menne1,2
1Department of Health Professions, University of Central Florida, Orlando, Florida (ND).
American Journal of Lifestyle Medicine
|September 12, 2018
Summary
The Reducing Disability in Alzheimer's Disease (RDAD) intervention did not significantly improve physical performance measures like gait speed, balance, or functional reach in individuals with dementia. Further research is needed to optimize exercise protocols for this population.
Area of Science:
- Gerontology
- Neuroscience
- Physical Therapy
Background:
- The Reducing Disability in Alzheimer's Disease (RDAD) intervention is designed to support individuals with dementia and their caregivers.
- Previous studies confirmed RDAD's efficacy, acceptability, and feasibility, but objective physical performance measures (PPM) were not assessed.
Purpose of the Study:
- To evaluate the impact of the RDAD intervention on objective physical performance measures (PPM) in individuals with dementia.
- To analyze changes in gait speed, functional reach, and balance following the RDAD program.
Main Methods:
- Data from the Replication of RDAD study (n=508) was used to test the hypothesis of PPM improvement.
- Statistical analysis was performed to identify changes in gait speed, balance, and functional reach.
Main Results:
- No significant changes were observed in gait speed (P =.81), balance (P = .82), or functional reach (P = .58) after the RDAD intervention.
- These nonfindings highlight the need for careful interpretation in exercise intervention research for dementia.
Conclusions:
- The RDAD intervention, as implemented, did not lead to significant improvements in the tested physical performance measures.
- Future intervention designs may need to consider exercise dosage based on fundamental principles or re-evaluate the alignment between intervention components and outcome measures for individuals with dementia.
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