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Updated: Feb 5, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Coordination-driven self-assembly vs dynamic covalent chemistry: versatile methods for the synthesis of molecular
Li-Li Ma1, Jia-Qin Han1,2, Wei-Guo Jia2
1Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.
Abstract:
Supramolecular coordination assemblies have a range of potential applications in chemical and biological sciences. Herein, simple modular methods for the synthesis of metallarectangles are described. The desired tetranuclear metallarectangles were synthesized by using coordination-driven self-assembly of half-sandwich rhodium-based organometallic clip units and organic ligands. The reaction of such an organometallic clip with 4-formylpyridine provided a dinuclear molecular tweezer with pendant aldehyde groups, and subsequent [4 + 4] condensation reactions with diamines provides another route to the target metallarectangles in good yields. The same assemblies can also be easily isolated in one-pot procedures by mixing the organometallic clip, diamines and 4-formylpyridine.
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