Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

"Low-" versus "high"-frequency oscillation and right ventricular function in ARDS. A randomized crossover study.

Spyros D Mentzelopoulos1, Hector Anninos1, Sotirios Malachias1

  • 1First Department of Intensive Care Medicine, National and Kapodestrian University of Athens Medical School, Evaggelismos General Hospital, 45-47 Ipsilandou Street, GR-10675 Athens, Greece.

Journal of Intensive Care
|September 12, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing palliative care in intensive care units: protocol of EPIC, a controlled, cluster-randomised, non-blinded stepped-wedge design trial with crossover phase.

BMJ open·2026
Same author

A Narrative Review on Current Status of Conscious Sedation for Transcatheter Aortic Valve Implantation.

Medicina (Kaunas, Lithuania)·2025
Same author

General Critical Care, Temperature Control, and End-of-Life Decision Making in Patients Resuscitated from Cardiac Arrest.

Journal of clinical medicine·2023
Same author

Mortality of intubated patients with COVID-19 during first and subsequent waves: a meta-analysis involving 363,660 patients from 43 countries.

Expert review of respiratory medicine·2022
Same author

Serum inflammatory and brain injury biomarkers in COVID-19 patients admitted to intensive care unit: A pilot study.

eNeurologicalSci·2022
Same author

Second- and Third-Tier Therapies for Severe Traumatic Brain Injury.

Journal of clinical medicine·2022

Low-frequency high-frequency oscillation (HFO) strategies, specifically 4-Hz HFO, improved right ventricular (RV) function in acute respiratory distress syndrome (ARDS) patients compared to high-frequency (7-Hz) HFO. These findings suggest 4-Hz HFO may be a safer ventilation strategy for ARDS.

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Cardiovascular Physiology

Background:

  • High-frequency oscillation (HFO) ventilation trials in acute respiratory distress syndrome (ARDS) have yielded negative results, potentially due to HFO-induced right ventricular (RV) dysfunction.
  • High intrathoracic pressures and hypercapnia during HFO may contribute to RV failure.

Purpose of the Study:

  • To investigate the impact of different HFO frequencies and tracheal gas insufflation on RV function in ARDS patients.
  • To compare the effects of 4-Hz HFO and 4-Hz HFO with tracheal gas insufflation (HFO-TGI) against 7-Hz HFO and conventional ventilation (CV) on RV function.

Main Methods:

  • 17 patients with moderate-to-severe ARDS were studied using transesophageal echocardiography (TEE) to assess RV function.
  • Patients underwent sequential ventilation with CV, 4-Hz HFO, 7-Hz HFO, and HFO-TGI, with RV function and gas exchange monitored.
Keywords:
AdultEchocardiographyHeart ventriclesHigh-frequency ventilationHypercapniaRespiratory distress syndromeTransesophageal

Related Experiment Videos

  • Positive end-expiratory pressure (PEEP) was optimized using TEE, and HFO mean airway pressure (mPaw) was titrated to maintain oxygen saturation.

    • Main Results:

    • 7-Hz HFO led to significantly worse RV function (higher RVEDA/LVEDA and eccentricity indexes) and higher PaCO2 compared to 4-Hz HFO and HFO-TGI.
    • 4-Hz HFO-TGI showed improved RV function compared to baseline CV.
    • All HFO strategies improved PaO2/FiO2, with minimal changes in cardiac index across ventilation modes.

    Conclusions:

    • Short-term application of 4-Hz HFO strategies in ARDS patients resulted in superior RV function compared to 7-Hz HFO.
    • Improved PaCO2 control with 4-Hz HFO strategies contributed to better RV function.
    • 4-Hz HFO strategies demonstrated similar or improved RV function compared to conventional ventilation, suggesting potential benefits for ARDS management.