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Updated: Feb 5, 2026
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Catheter-Based Renal Denervation for Hypertension
Raymond R Townsend1, Paul A Sobotka2,3
1Perelman School of Medicine, Renal, Electrolyte and Hypertension Division, University of Pennsylvania, 122 Founders Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA. townsend@upenn.edu.
Insights
Therapeutic renal denervation offers a moderate blood pressure reduction for hypertension. Further research is needed to identify optimal patient candidates for this interventional procedure.
Area of Science:
- Cardiovascular medicine
- Interventional cardiology
- Nephrology
Background:
- The field of therapeutic renal denervation for hypertension has seen significant advancements between 2016 and 2018.
- Following the Symplicity HTN-3 trial's outcome, research has focused on refining device technology, improving patient monitoring for medication adherence, and enhancing procedural techniques for deeper renal artery access.
Purpose of the Study:
- To provide an updated review of therapeutic renal denervation for hypertension.
- To analyze recent findings and advancements in the field from 2016 to 2018.
Main Methods:
- Review of recent scientific literature and clinical investigations.
- Analysis of studies focusing on improved renal denervation technologies and patient selection.
Main Results:
- Renal denervation demonstrates a consistent, albeit moderate, reduction in blood pressure.
- The procedure shows efficacy in both medication-treated and untreated hypertensive patients.
- Approximately one-third of patients do not respond to renal denervation, indicating a need for better patient stratification.
Conclusions:
- Therapeutic renal denervation remains a viable option for hypertension management, offering moderate blood pressure control.
- Improvements in technology and patient monitoring have addressed previous concerns.
- Further investigation into patient selection criteria is crucial to optimize outcomes and improve response rates in renal denervation therapy.
Purpose Of Review:
This review was undertaken to update readers on the field of therapeutic renal denervation for hypertension during the 2016 through 2018 period.
Recent Findings:
After the failure of Symplicity HTN-3 to meet its top line objective, intense scrutiny revealed several possible concerns addressed by the newer investigations into the area of renal denervation. These included better device technology, more intense subject monitoring for off-protocol antihypertensive drug usage, and deeper penetration into the renal vasculature by the interventionist. Whether untreated by medication for hypertension or on antihypertensive medication, renal denervation shows a clear, though moderate, blood pressure reduction. The failure of roughly one out of three patients with hypertension to respond to denervation procedures argues that there is room for improvement in choosing the optimal patient for this approach to hypertension management.
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