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Catheter-Based Renal Denervation for Hypertension.

Raymond R Townsend1, Paul A Sobotka2,3

  • 1Perelman School of Medicine, Renal, Electrolyte and Hypertension Division, University of Pennsylvania, 122 Founders Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA. townsend@upenn.edu.

Current Hypertension Reports
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PubMed
Summary

Therapeutic renal denervation offers a moderate blood pressure reduction for hypertension. Further research is needed to identify optimal patient candidates for this interventional procedure.

Keywords:
Alcohol ablationHypertensionRadiofrequency ablationRenal denervationUltrasound ablation

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Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Nephrology

Background:

  • The field of therapeutic renal denervation for hypertension has seen significant advancements between 2016 and 2018.
  • Following the Symplicity HTN-3 trial's outcome, research has focused on refining device technology, improving patient monitoring for medication adherence, and enhancing procedural techniques for deeper renal artery access.

Purpose of the Study:

  • To provide an updated review of therapeutic renal denervation for hypertension.
  • To analyze recent findings and advancements in the field from 2016 to 2018.

Main Methods:

  • Review of recent scientific literature and clinical investigations.
  • Analysis of studies focusing on improved renal denervation technologies and patient selection.

Main Results:

  • Renal denervation demonstrates a consistent, albeit moderate, reduction in blood pressure.
  • The procedure shows efficacy in both medication-treated and untreated hypertensive patients.
  • Approximately one-third of patients do not respond to renal denervation, indicating a need for better patient stratification.

Conclusions:

  • Therapeutic renal denervation remains a viable option for hypertension management, offering moderate blood pressure control.
  • Improvements in technology and patient monitoring have addressed previous concerns.
  • Further investigation into patient selection criteria is crucial to optimize outcomes and improve response rates in renal denervation therapy.