Annulation of β-Enaminonitriles with Alkynes via Rh
Haili Wang1, Hong Xu1, Bin Li1
1State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Abstract:
A Cp*RhIII-catalyzed oxidative annulation of β-enaminonitriles with alkynes was reported to achieve selective synthesis of polysubstituted 1-naphthylamines and naphtho[1,8- bc]pyridines via multiple C-H activations. Assisted by a naphthylamine NH2 group, 1-naphthylamines were also readily cyclized to produce naphtho[1,8- bc]pyridines. In addition, the obtained naphtho[1,8- bc]pyridine derivatives exhibit intense fluorescence in the solid state.
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